SNAP-25 Polymorphisms in Autism Spectrum Disorder: A Pilot Study towards a Possible Endophenotype.

While there is substantial agreement on the diagnostic criteria for autism spectrum disorder, it is also acknowledged that it has a broad range of clinical presentations. This can complicate the diagnostic process and aggravate the choice of the most suitable rehabilitative strategy for each child. Attentional difficulties are among the most frequently reported comorbidities in autism spectrum disorder. We investigated the role of SNAP-25 polymorphisms. Synaptosome-associated protein 25 (SNAP25) is a presynaptic membrane-binding protein; it plays a crucial role in neurotransmission and has already been studied in numerous psychiatric disorders. It was also seen to be associated with hyperactivity in children with autism spectrum disorder. We collected clinical, behavioral and neuropsychological data on 41 children with a diagnosis of autism spectrum disorder, and then genotyped them for five single-nucleotide polymorphisms of SNAP-25. Participants were divided into two groups according to the Autism Diagnostic Observation Schedule (ADOS-2) Severity Score. In the group with the highest severity score, we found significant associations of clinical data with polymorphism rs363050 (A/G): children with the GG genotype had lower total IQ, more severe autistic functioning and more attentional difficulties. Our research could be the starting point for outlining a possible endophenotype among patients with autism spectrum disorder who are clinically characterized by severe autistic functioning and significant attentional difficulties.

Lactobacillus plantarum PS128 and Other Probiotics in Children and Adolescents with Autism Spectrum Disorder: A Real-World Experience.

Autism Spectrum Disorder is a neurodevelopmental disorder. Recent data suggest that probiotics can reduce some symptoms of this disorder and Lactobacillus plantarum PS128 has been reported to be especially useful. We recruited a sample of 131 autistic children and adolescents (M:F = 122:19; age: 86.1 ± 41.1 months) and evaluated their changes after use of probiotics by mean of CGI. We found some significant improvements with very few side effects; these positive effects were more evident in younger children. Patients taking Lactobacillus plantarum PS128 had greater improvements and fewer side effects than those taking other probiotics. Our real-life data are consistent with existing literature showing a specific effect of Lactobacillus plantarum PS128 in Autism Spectrum Disorder.

Predictions of bitcoin prices through machine learning based frameworks.

The high volatility of an asset in financial markets is commonly seen as a negative factor. However short-term trades may entail high profits if traders open and close the correct positions. The high volatility of cryptocurrencies, and in particular of Bitcoin, is what made cryptocurrency trading so profitable in these last years. The main goal of this work is to compare several frameworks each other to predict the daily closing Bitcoin price, investigating those that provide the best performance, after a rigorous model selection by the so-called k-fold cross validation method. We evaluated the performance of one stage frameworks, based only on one machine learning technique, such as the Bayesian Neural Network, the Feed Forward and the Long Short Term Memory Neural Networks, and that of two stages frameworks formed by the neural networks just mentioned in cascade to Support Vector Regression. Results highlight higher performance of the two stages frameworks with respect to the correspondent one stage frameworks, but for the Bayesian Neural Network. The one stage framework based on Bayesian Neural Network has the highest performance and the order of magnitude of the mean absolute percentage error computed on the predicted price by this framework is in agreement with those reported in recent literature works.

Forecasting Bitcoin closing price series using linear regression and neural networks models.

In this article we forecast daily closing price series of Bitcoin, Litecoin and Ethereum cryptocurrencies, using data on prices and volumes of prior days. Cryptocurrencies price behaviour is still largely unexplored, presenting new opportunities for researchers and economists to highlight similarities and differences with standard financial prices. We compared our results with various benchmarks: one recent work on Bitcoin prices forecasting that follows different approaches, a well-known paper that uses Intel, National Bank shares and Microsoft daily NASDAQ closing prices spanning a 3-year interval and another, more recent paper which gives quantitative results on stock market index predictions. We followed different approaches in parallel, implementing both statistical techniques and machine learning algorithms: the Simple Linear Regression (SLR) model for uni-variate series forecast using only closing prices, and the Multiple Linear Regression (MLR) model for multivariate series using both price and volume data. We used two artificial neural networks as well: Multilayer Perceptron (MLP) and Long short-term memory (LSTM). While the entire time series resulted to be indistinguishable from a random walk, the partitioning of datasets into shorter sequences, representing different price "regimes", allows to obtain precise forecast as evaluated in terms of Mean Absolute Percentage Error(MAPE) and relative Root Mean Square Error (relativeRMSE). In this case the best results are obtained using more than one previous price, thus confirming the existence of time regimes different from random walks. Our models perform well also in terms of time complexity, and provide overall results better than those obtained in the benchmark studies, improving the state-of-the-art.

Modeling and Simulation of the Economics of Mining in the Bitcoin Market.

In January 3, 2009, Satoshi Nakamoto gave rise to the "Bitcoin Blockchain", creating the first block of the chain hashing on his computer's central processing unit (CPU). Since then, the hash calculations to mine Bitcoin have been getting more and more complex, and consequently the mining hardware evolved to adapt to this increasing difficulty. Three generations of mining hardware have followed the CPU's generation. They are GPU's, FPGA's and ASIC's generations. This work presents an agent-based artificial market model of the Bitcoin mining process and of the Bitcoin transactions. The goal of this work is to model the economy of the mining process, starting from GPU's generation, the first with economic significance. The model reproduces some "stylized facts" found in real-time price series and some core aspects of the mining business. In particular, the computational experiments performed can reproduce the unit root property, the fat tail phenomenon and the volatility clustering of Bitcoin price series. In addition, under proper assumptions, they can reproduce the generation of Bitcoins, the hashing capability, the power consumption, and the mining hardware and electrical energy expenditures of the Bitcoin network.